Pemafibrate, a selective PPARα modulator, and fenofibrate suppress microglial activation through distinct PPARα and SIRT1-dependent pathways
Kento Ogawa, Takashi Yagi, Tingting Guo, K Takeda, Hideomi Ohguchi, Hiroyuki Koyama, Daisuke Aotani, Kenro Imaeda, Hiromi Kataoka, Tomohiro Tanaka
Topics & Concepts
Gene knockdownFenofibratePeroxisome proliferator-activated receptorActivator (genetics)ChemistrySirtuin 1ReceptorCell biologyMicrogliaDownregulation and upregulationInflammationBiochemistryBiologyPharmacologyApoptosisImmunologyGenePeroxisome Proliferator-Activated ReceptorsNeuroinflammation and Neurodegeneration MechanismsAdenosine and Purinergic Signaling