Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72
Qiang Zhu, Jie Jiang, Tania F. Gendron, Melissa McAlonis‐Downes, Lu-Lin Jiang, Amy E. Taylor, Sandra Diaz Garcia, Somasish Ghosh Dastidar, María José Gómez-Rodríguez, Patrick King, Yong‐Jie Zhang, Albert R. La Spada, Huaxi Xu, Leonard Petrucelli, John Ravits, Sandrine Da Cruz, Clotilde Lagier‐Tourenne, Don W. Cleveland
Topics & Concepts
C9orf72Trinucleotide repeat expansionAmyotrophic lateral sclerosisBiologyFrontotemporal dementiaTransgeneAutophagyGeneticsAlleleCell biologyDementiaMedicineGeneInternal medicineDiseaseApoptosisAmyotrophic Lateral Sclerosis ResearchParkinson's Disease Mechanisms and TreatmentsNeurogenetic and Muscular Disorders Research