The induction of AMPK-dependent autophagy leads to P53 degradation and affects cell growth and migration in kidney cancer cells
Simone Patergnani, Sonia Guzzo, Alessandra Mangolini, Lucio Dell’Atti, Paolo Pinton, Gianluca Aguiari
Topics & Concepts
AutophagyDownregulation and upregulationBiologyAMPKCancer researchCell biologyProgrammed cell deathPI3K/AKT/mTOR pathwayClear cell renal cell carcinomaCancer cellCell growthCancerCellApoptosisKinaseProtein kinase ASignal transductionRenal cell carcinomaInternal medicineBiochemistryMedicineGeneGeneticsAutophagy in Disease and TherapyCancer-related Molecular PathwaysMetabolism, Diabetes, and Cancer