Platelet mediated TRAIL delivery for efficiently targeting circulating tumor cells
Nerymar Ortiz-Otero, Jocelyn R. Marshall, Bradley W. Lash, Michael R. King
Abstract
" platelet modification. This platelet-mediated TRAIL delivery significantly reduced the viability of colorectal and breast cancer cells circulating in flowing blood under physiological shear conditions. TRAIL-coated platelets significantly killed over 60% of CTCs in flowing blood from a variety of primary metastatic cancer samples. Platelets have been considered an important player in the regulation of metastasis due to their interaction with cancer cells in the circulation; the current study supports the idea of using platelet-based TRAIL delivery as a promising CTC-targeted cancer therapy.
Topics & Concepts
Circulating tumor cellPlateletExtravasationMetastasisCancer cellCancer researchMedicinePlatelet activationCancerColorectal cancerImmunologyInternal medicineCancer, Stress, Anesthesia, and Immune ResponseNanoplatforms for cancer theranosticsImmune cells in cancer