Analysis of the Oxidative Stress Regulon Identifies <i>soxS</i> as a Genetic Target for Resistance Reversal in Multidrug-Resistant Klebsiella pneumoniae
João Anes, Katherine Dever, Athmanya K. Eshwar, Scott V. Nguyen, Yu Cao, Sathesh K. Sivasankaran, Sandra Sakalauskaitė, Angelika Lehner, Stéphanie Devineau, Rimantas Daugelavičius, Roger Stephan, Séamus Fanning, Shabarinath Srikumar
Abstract
Antimicrobial resistance is a global health challenge. Few new antibiotics have been developed for use over the years, and preserving the efficacy of existing compounds is an important step to protect public health. This paper describes a study that examines the effects of exogenously induced oxidative stress on K. pneumoniae and uncovers a target that could be useful to harness as a strategy to mitigate resistance.
Topics & Concepts
RegulonKlebsiella pneumoniaeMultiple drug resistanceAntibiotic resistanceOxidative stressMicrobiologyAntimicrobialDrug resistanceBiologyAntibioticsBacterial proteinGeneGeneticsEscherichia coliBiochemistryAntibiotic Resistance in BacteriaCancer therapeutics and mechanismsAntimicrobial Peptides and Activities