<i>In vitro</i> cytotoxic capacity against tumor cell lines and antioxidant activity of acidic polysaccharides isolated from the Andean Patagonian fungus <i>Phylloporia boldo</i>
Verónica Albornoz, Virginia Casas-Arrojo, Fabián Figueroa, Cristian Riquelme, Víctor Hernández, Mario Rajchenberg, Carlos T. Smith, Víctor Campos, Roberto Abdala‐Díaz, José Becerra, Claudia Pérez, Jaime R. Cabrera‐Pardo
Abstract
acidic polysaccharides arrested tumor cells in the cell cycle Sub G1 phase. The acidic polysaccharides of PBAP40 strain were not cytotoxic for the non-tumor cell line. PBAP40 also showed excellent antioxidant activity. The FT-IR analysis of the acidic polysaccharides indicated the presence of glucans bearing α- and β- type glycosidic bonds.
Topics & Concepts
PolysaccharideCytotoxic T cellAntioxidantChemistryBiochemistryCell cultureDPPHViability assayMTT assayABTSCytotoxicityIn vitroBiologyGeneticsFungal Biology and ApplicationsPolysaccharides and Plant Cell WallsBiocrusts and Microbial Ecology