C–H Activation by Isolable Cationic Bis(phosphine) Cobalt(III) Metallacycles
William G. Whitehurst, Junho Kim, Stefan G. Koenig, Paul J. Chirik
Abstract
-alkylated products, consistent with the selectivity of reported cobalt-catalyzed arene-alkene-alkyne coupling reactions. The direct observation of C-H activation by cobalt(III) metallacycles provided experimental support for the intermediacy of these compounds in this class of catalytic C-H functionalization reaction. Deuterium labeling and kinetic studies provided insight into the nature of C-H bond cleavage and C-C bond reductive elimination from isolable cobalt(III) precursors.
Topics & Concepts
ChemistryPhosphineCobaltCationic polymerizationAlkeneMetallacycleMedicinal chemistryAlkyneSelectivityCatalysisBond cleavageCarbeneReductive eliminationStereochemistryPolymer chemistryOrganic chemistryDiffractionX-ray crystallographyPhysicsOpticsCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsAsymmetric Hydrogenation and Catalysis