Role of Mandukparni (Centella asiatica Linn Urban) in neurological disorders: Evidence from ethnopharmacology and clinical studies to network enrichment analysis
Ruchi Sharma, Ruchi Sharma, Subhadip Banerjee, Rohit Sharma, Rohit Sharma
Abstract
Centella asiatica Linn Urban ( C. asiatica ), aka Mandukparni , is one of the flagship herbs used in traditional medicines to effectively manage neurological problems. Although this plant has a wealth of comprehensive preclinical pharmacological profiles, further clinical research and execution of its molecular mode of action are still required. We searched electronic databases (Google Scholar, SciFinder, MEDLINE, Scopus, EMBASE, Science Direct, and PubMed) using relevant key words to retrieve information pertaining to C. asiatica till June 2023 and performed network pharmacology to understand the mechanism related to their neurobiological roles. This study extensively analyses its pharmacological properties, nutritional profile, ethnomedical uses, safety, and mechanistic role in treating neurological and neurodegenerative disorders. Additionally, a network pharmacology study was performed which suggests that its phytomolecules are involved in different neuroactive ligand-receptor pathways, glial cell differentiation, gliogenesis, and astrocyte differentiation. Hopefully, this report will lead to a paradigm shift in medical practice, research, and the creation of phytopharmaceuticals derived from C. asiatica that target the central nervous system. • Centella asiatica is one of the flagship herbs used in Ayurveda and pharma industry to treat neurological problems and improving learning and memory. • Its rich bioactive constituents are reported to be highly effective in improving learning and memory. • Network pharmacology shows its role in different neuroactive ligand-receptor pathways, gliogenesis, glial cell and astrocyte differentiation.