Quantitative 1H and 23Na muscle MRI in Facioscapulohumeral muscular dystrophy patients
Teresa Gerhalter, Benjamin Marty, Lena V. Gast, Katharina Porzelt, Rafael Heiss, Michael Uder, Stefan Schwab, Pierre G. Carlier, Armin M. Nagel, Matthias Türk
Abstract
Abstract Objective Our aim was to assess the role of quantitative 1 H and 23 Na MRI methods in providing imaging biomarkers of disease activity and severity in patients with Facioscapulohumeral muscular dystrophy (FSHD). Methods We imaged the lower leg muscles of 19 FSHD patients and 12 controls with a multimodal MRI protocol to obtain STIR-T 2 w images, fat fraction (FF), water T 2 (wT 2 ), water T 1 (wT 1 ), tissue sodium concentration (TSC), and intracellular-weighted sodium signal (inversion recovery (IR) and triple quantum filter (TQF) sequence). In addition, the FSHD patients underwent muscle strength testing. Results Imaging biomarkers related with water mobility (wT 1 and wT 2 ) and ion homeostasis (TSC, IR, TQF) were increased in muscles of FSHD patients. Muscle groups with FF > 10% had higher wT 2 , wT 1 , TSC, IR, and TQF values than muscles with FF < 10%. Muscles with FF < 10% resembled muscles of healthy controls for these MRI disease activity measures. However, wT 1 was increased in few muscles without fat replacement. Furthermore, few STIR-negative muscles ( n = 11/76) exhibited increased wT 1 , TSC, IR or TQF. Increased wT 1 as well as 23 Na signals were also present in muscles with normal wT 2 . Muscle strength was related to the mean FF and all imaging biomarkers of tibialis anterior except wT 2 were correlated with dorsal flexion. Conclusion The newly evaluated imaging biomarkers related with water mobility (wT 1 ) and ion homeostasis (TSC, IR, TQF) showed different patterns compared to the established markers like FF in muscles of FSHD patients. These quantitative biomarkers could thus contain valuable complementary information for the early characterization of disease progression.