Guignardones Y–Z, Antiviral Meroterpenes from <i>Penicillium</i> sp. NBUF154 Associated with a <i>Crella</i> Sponge from the Marine Mesophotic Zone
Jiabin Zou, Jialing Wu, Lijian Ding, Weiyi Wang, Yinghui Liu, Yunping Feng, Qiliang Lai, Wenhan Lin, Tingting Wang, Shan He
Abstract
Guignardones Y-Z (1-2), two new meroterpenoids, and six known metabolites involving guignardones A-H (3-4), gyorgy-isoflavone (5), daidzein (6), blumenol A (7) and guignardianone A (8) were isolated from the fungus Penicillium sp. NBUF154, which was obtained from a 60 m deep Crella sponge. Their structures including absolute configurations were unambiguously elucidated by exhaustive spectroscopic analysis and ECD calculations. A putative biosynthetic pathway toward guignardones (1-4) is here proposed. Biological evaluation of compounds 1-8 showed that 1 and 7 exert potent inhibitory effects towards human enterovirus 71 (EV71).