Suppression of lncRNA SNHG15 protects against cerebral ischemia-reperfusion injury by targeting miR-183-5p/FOXO1 axis.
Ya Wen, Xiangjian Zhang, Xiaoyun Liu, Yinghao Huo, Yuxiao Gao, Yi Yang
Abstract
BACKGROUND: Cerebral ischemia/reperfusion (I/R) injury is a severe complication during the treatment of patients with stroke. It has been shown that the expression of SNHG15 was increased in patients with ischemic stroke (IS). However, the function and regulatory mechanism of SNHG15 in IS remains unclear. METHODS: model of cerebral I/R injury. RESULTS: inhibited neuronal apoptosis and decreased infarct area in MCAO rats. CONCLUSION: Thus, the present study indicated that SNHG15 knockdown protected against cerebral I/R injury via targeting miR-183-5p/FOXO1 axis, which may represent a potential therapeutic option for the treatment of cerebral IS.
Topics & Concepts
Gene knockdownDownregulation and upregulationApoptosisPI3K/AKT/mTOR pathwayReperfusion injuryIschemiaProtein kinase BSH-SY5YMedicineIn vivoPharmacologyChemistryInternal medicineBiologyCell cultureBiochemistryBiotechnologyGeneNeuroblastomaGeneticsCancer-related molecular mechanisms researchCircular RNAs in diseasesMicroRNA in disease regulation