Deficiency of arcuate nucleus kisspeptin results in postpubertal central hypogonadism
Nimisha Nandankar, Ariel L Negrón, Andrew Wolfe, Jon E. Levine, Sally Radovick
Abstract
We demonstrate through a novel, conditional knockout mouse model of arcuate nucleus (ARC)-specific kisspeptin in the KNDy neuron that ARC kisspeptin is critical for estrous cyclicity in female mice and GnRH/LH pulsatility in both sexes. Our study reveals that ARC kisspeptin is essential for normal gametogenesis, and the loss of ARC kisspeptin results in significant hypogonadism, impacting fertility status. Our findings further confirm that normal puberty occurs despite a loss of ARC kisspeptin.
Topics & Concepts
KisspeptinArc (geometry)Arcuate nucleusEndocrinologyInternal medicineEstrous cycleConditional gene knockoutBiologyMedicineHypothalamusGenePhenotypeGeneticsMathematicsGeometryHypothalamic control of reproductive hormonesPlant Reproductive BiologyRegulation of Appetite and Obesity