Disrupting autorepression circuitry generates “open-loop lethality” to yield escape-resistant antiviral agents
Sonali Chaturvedi, Michael Pablo, Marie Wolf, Daniel Rosas-Rivera, Giuliana Calia, Arjun J. Kumar, Noam Vardi, Kelvin Du, Joshua Glazier, Ruian Ke, Matilda F. Chan, Alan S. Perelson, Leor S. Weinberger
Topics & Concepts
BiologyLethalityYield (engineering)Cell biologySynthetic lethalityGeneticsMutantGeneMetallurgyMaterials scienceViral Infections and Immunology ResearchRNA and protein synthesis mechanismsinterferon and immune responses