Caspase-3 knockout attenuates radiation-induced tumor repopulation via impairing the ATM/p53/Cox-2/PGE2 pathway in non-small cell lung cancer
Minghui Zhao, Yiwei Wang, Yucui Zhao, Sijia He, Ruyi Zhao, Yanwei Song, Jin Cheng, Yanping Gong, Jianzhu Xie, Yulan Wang, Binjie Hu, Ling Tian, Qian Huang
Abstract
signaling pathway could provide potential therapeutic targets to reduce NSCLC recurrence after radiotherapy.
Topics & Concepts
RepopulationCancer researchApoptosisLung cancerKnockout mouseMedicineChemistryBiologyInternal medicineCell biologyStem cellReceptorBiochemistryHaematopoiesisPARP inhibition in cancer therapyCell death mechanisms and regulationCancer-related Molecular Pathways