Pyrosulfite-Involved Synthesis of Sulfides by Palladium-Catalyzed Decarboxylative Couplings
Xiaokang Li, Bei Wei, Yanlong Gong, Chengyi Li, Xiaoting Liu, Bin Liu, Qingshan Li, Shurong Ban
Abstract
The decarboxylative coupling using carboxylic acid and potassium metabisulfite, promoted by a palladium catalyst, is reported for the generation of sulfides. The coupling is performed using the easily available carboxylic acid and environmentally friendly inorganic sulfides as a divalent inorganic sulfur source. Not only aromatic acids but also aliphatic carboxylic acids are workable during the couplings. The method is applicable and practical to a scope of 20 examples and drug molecules.
Topics & Concepts
PalladiumCatalysisChemistrySulfurEnvironmentally friendlyCarboxylic acidOrganic chemistryMoleculeCombinatorial chemistryEcologyBiologySulfur-Based Synthesis TechniquesChemical Synthesis and ReactionsRadical Photochemical Reactions