Intestinal epithelial damage-derived mtDNA activates STING-IL12 axis in dendritic cells to promote colitis
Yajie Cai, Shuo Li, Yang Yang, Shuni Duan, Guifang Fan, Jinzhao Bai, Qi Zheng, Yiqing Gu, Xiaojiaoyang Li, Runping Liu
Abstract
Detection of the TFAM-mtDNA complex from damaged intestinal epithelium by myeloid STING exacerbates colitis through IL-12 cytokines, providing new evidence to support the development of STING as a therapeutic target for UC and CAC.
Topics & Concepts
StingColitisUlcerative colitisCancer researchMedicineImmunologyPathologyDiseaseAerospace engineeringEngineeringinterferon and immune responsesInflammasome and immune disordersCytokine Signaling Pathways and Interactions