<i>Ascaris suum</i> Informs Extrasynaptic Volume Transmission in Nematodes
Louise E. Atkinson, Yang Liu, Fiona M. McKay, Elke Vandewyer, Charles Viau, Allister Irvine, Bruce A. Rosa, Zihui Li, Qingxiao Liang, Nikki J. Marks, Aaron G. Maule, Makedonka Mitreva, Isabel Beets, Lingjun Li, Angela Mousley
Abstract
behavior, and (vi) FLP-18 and FLP-18 receptors display pan-phylum distribution in nematodes. This study provides the first direct experimental evidence to support an extrasynaptic volume route for neuropeptide transmission in nematodes. These data indicate nonsynaptic signaling within the nematode functional connectome and are particularly pertinent to receptor deorphanization approaches underpinning drug discovery programs for nematode pathogens.
Topics & Concepts
Ascaris suumFMRFamideNeuropeptideBiologyCaenorhabditis elegansNematodeNeurotransmissionCell biologyReceptorNeuroscienceImmunologyBiochemistryEcologyHelminthsGeneGenetics, Aging, and Longevity in Model OrganismsNeuroendocrine regulation and behaviorCircadian rhythm and melatonin