H-BPin/KO<sup><i>t</i></sup>Bu Promoted Activation of Cobalt Salt to a Heterotopic Catalyst for Highly Selective Cyclotrimerization of Alkynes
Shuo Song, Chuhan Li, Tianfen Liu, Panke Zhang, Xiaoming Wang
Abstract
Bu was found to activate cobalt salt to form a heterotopic cobalt species that is highly active for catalytic intermolecular trimerization of alkynes. This protocol affords 1,2,4-regioisomers in good yields with high regioselectivities under mild conditions. These salient features, together with the operational simplicity and high efficiency, as well as obviating the use of any costly and/or air sensitive ligands, renders the protocol promising for practical applications.
Topics & Concepts
ChemistryCobaltCatalysisSalt (chemistry)Combinatorial chemistryStructural isomerProtocol (science)Medicinal chemistryStereochemistryOrganic chemistryAlternative medicineMedicinePathologyCatalytic C–H Functionalization MethodsCatalytic Alkyne ReactionsCyclopropane Reaction Mechanisms