Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective
Mohammed Iqbal Hossain, Joshua M. Marcus, Jun Hee Lee, Patrick L. Garcia, Vinodkumar Singh, John J. Shacka, Jianhua Zhang, Toby Gropen, Charles N. Falany, Shaida A. Andrabi
Abstract
3-MA: 3-methyladenine; ACTB: actin beta; AD: Alzheimer disease; ALS: amyotrophic lateral sclerosis; CQ: chloroquine; CTSB: cathepsin B; CTSD: cathepsin D; CTSL: cathepsin L; FTD: frontotemporal dementia, HD: Huntington disease; LAMP1: lysosomal associated membrane protein 1; LSD: lysosomal storage disease; MCAO: middle cerebral artery occlusion; OGD: oxygen glucose deprivation; OGR: oxygen glucose resupply; PD: Parkinson disease; SQSMT1: sequestosome 1; TCA: trichloroacetic acid; TTC: triphenyl tetrazolium chloride.
Topics & Concepts
Cathepsin DNeuroprotectionBiologyCathepsinCell biologyNeuroscienceBiochemistryEnzymeAutophagy in Disease and TherapyAlzheimer's disease research and treatmentsParkinson's Disease Mechanisms and Treatments