Inhibition of Biofilm Formation and Virulence Factors of Cariogenic Oral Pathogen Streptococcus mutans by Shikimic Acid
Zhang Zhong, Yang Yang, Qun Sun, Wei‐Cai Zeng, Yuqing Li
Abstract
Natural products are an important and cost-effective source for screening antimicrobial agents. Here, we identified one compound, shikimic acid, from Illicium verum extract, exhibiting antimicrobial activity against S. mutans proliferation. It also inhibits biofilm formation of this bacteria through decreasing Gtf expression and EPS synthesis. Furthermore, this compound exhibits no significant cytotoxicity at its MIC against S. mutans , providing evidence for its clinical application.
Topics & Concepts
BiofilmStreptococcus mutansShikimic acidMicrobiologyAntimicrobialVirulencePathogenBacteriaChemistryCytotoxicityBiologyIn vitroBiochemistryGeneGeneticsOral microbiology and periodontitis researchInfections and bacterial resistanceNatural product bioactivities and synthesis