Highlighting fibroblast plasticity in lung fibrosis: the WI-38 cell line as a model for investigating the myofibroblast and lipofibroblast switch
Esmeralda Vásquez‐Pacheco, Manuela Marega, Arun Lingampally, Julien Fassy, Marin Truchi, Kerstin Goth, Lisa Trygub, Sara Taghizadeh, Marek Bartkuhn, Ioannis Alexopoulos, Ying Dong, Kévin Lebrigand, Andreas Gunther, Chengshui Chen, JinSan Zhang, Cho‐Ming Chao, Denise Al Alam, Elie El Agha, Bernard Mari, Saverio Bellusci, Stefano Rivetti
Abstract
WI-38 cells represent a versatile and reliable model to study the intricate dynamics of fibroblast differentiation towards the MYF or LIF phenotype associated with lung fibrosis formation and resolution, providing valuable insights to drive future research.
Topics & Concepts
MyofibroblastFibroblastFibrosisExtracellular matrixPulmonary fibrosisLungIdiopathic pulmonary fibrosisPathologyLung fibrosisPathogenesisCancer researchCell biologyCell cultureBiologyMedicineInternal medicineGeneticsInterstitial Lung Diseases and Idiopathic Pulmonary FibrosisNeonatal Respiratory Health ResearchMedical Imaging and Pathology Studies