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Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy

Yan Zhao, Xinping Huang, Dan Zhu, Min Wei, Jiechen Luo, Shuyu Yu, Yonglu Tian, Xiaofeng Zheng

2022Cell Death and Differentiation48 citationsDOIOpen Access PDF

Topics & Concepts

DNA damageDeubiquitinating enzymeGenome instabilityUbiquitin ligaseCancer researchUbiquitinBiologyCell cycle checkpointCell growthDNA repairCarcinogenesisCell biologyCell cycleCancerDNAGeneGeneticsUbiquitin and proteasome pathwaysDNA Repair MechanismsCancer-related Molecular Pathways
Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy | Litcius