CXCL-8-dependent and -independent neutrophil activation in COPD: experiences from a pilot study of the CXCR2 antagonist danirixin
Holly R. Keir, Hollian Richardson, Christina Fillmore, Amelia Shoemark, Aili L. Lazaar, Bruce E. Miller, Ruth Tal‐Singer, James D. Chalmers, Divya Mohan
Abstract
<b>The implications of these findings are significant for development of CXCR2 antagonists and other mechanisms targeting neutrophil activation or NETosis, suggesting that IL-8-dependent mechanisms will only work in a subset of COPD patients</b>https://bit.ly/32SeisO
Topics & Concepts
MedicineCOPDAntagonistCXC chemokine receptorsNeutrophileNeutrophil extracellular trapsInterleukin 8ImmunologyReceptorChemokineInternal medicineInflammationChemokine receptorNeutrophil, Myeloperoxidase and Oxidative MechanismsInflammation biomarkers and pathwaysAntifungal resistance and susceptibility