Calcium-Permeable AMPA Receptors Promote Endocannabinoid Signaling at Parvalbumin Interneuron Synapses in the Nucleus Accumbens Core
Kevin M. Manz, Dipanwita Ghose, Brandon D. Turner, Anne Taylor, Jennifer C. Becker, Carrie A. Grueter, Brad A. Grueter
Abstract
Rs). Moreover, CP-AMPARs authorize tonic eCB signaling to negatively regulate glutamate release probability. Blockade of CP-AMPARs in the NAc core in vivo is sufficient to disinhibit locomotor output. These findings elucidate mechanisms by which PV-IN-embedded microcircuits in the NAc undergo activity-dependent shifts in synaptic strength.
Topics & Concepts
ParvalbuminGlutamatergicNeuroscienceNucleus accumbensAMPA receptorInterneuronSynaptic plasticityMedium spiny neuronEndocannabinoid systemGABAergicChemistryGlutamate receptorLong-term depressionBiologyReceptorInhibitory postsynaptic potentialBasal gangliaDopamineCentral nervous systemBiochemistryNeuroscience and Neuropharmacology ResearchSleep and Wakefulness ResearchZebrafish Biomedical Research Applications