The Molecular Mechanisms and Function of miR-15a/16 Dysregulation in Fibrotic Diseases
Dada Wen, Huamin Zhang, Yutong Zhou, Jie Wang
Abstract
MicroRNAs (miRNAs) are a class of short, endogenous, non-coding, single-stranded RNAs that can negatively regulate the post-transcriptional expression of target genes. Among them, miR-15a/16 is involved in the regulation of the occurrence and development of fibrosis in the liver, lungs, heart, kidneys, and other organs, as well as systemic fibrotic diseases, affecting important cellular functions, such as cell transformation, the synthesis and degradation of extracellular matrix, and the release of fibrotic mediators. Therefore, this article reviews the biological characteristics of miR-15a/16 and the molecular mechanisms and functions of their dysregulation in fibrotic diseases.
Topics & Concepts
microRNAExtracellular matrixFibrosisBiologyEndogenyCell biologyFunction (biology)Cancer researchGeneMedicineGeneticsPathologyEndocrinologyMicroRNA in disease regulationCircular RNAs in diseasesCancer-related molecular mechanisms research