Eosinophilic inflammation promotes CCL6-dependent metastatic tumor growth
Fei Li, Xufei Du, Fen Lan, Na Li, Chao Zhang, Chen Zhu, Xiaohui Wang, Yicheng He, Zhehua Shao, Hạixia Chen, Man Luo, Wen Li, Zhihua Chen, Songmin Ying, Huahao Shen
Abstract
Tg mice remarkably attenuates bone metastasis. Moreover, inhibition of C-C chemokine receptor 1 (CCR1, the receptor of CCL6) in tumor cells reduces tumor cell migration and metastasis. Thus, our study identifies a CCL6-dependent prometastatic activity of eosinophils, which can be inhibited by targeting CCR1 and represent an approach to preventing metastatic disease.
Topics & Concepts
InflammationCancer researchEosinophilicMedicineBiologyPathologyImmunologyImmune Cell Function and InteractionEosinophilic Disorders and SyndromesImmune cells in cancer