The sGC-cGMP Signaling Pathway as a Potential Therapeutic Target in Doxorubicin-Induced Heart Failure: A Narrative Review
Haneul Cho, Xiao-Xiao Zhao, Sora Lee, Jong Shin Woo, Min‐Young Song, Xian Wu Cheng, Kyung Hye Lee, Weon Kim
Topics & Concepts
CardiotoxicityPharmacologyMedicineCyclic guanosine monophosphateNitric oxideDoxorubicinSoluble guanylyl cyclaseSignal transductioncGMP-specific phosphodiesterase type 5PhosphodiesteraseApoptosisCancer researchSildenafilCell biologyChemistryBiologyBiochemistryInternal medicineEnzymeChemotherapyGuanylate cyclaseChemotherapy-induced cardiotoxicity and mitigationNitric Oxide and Endothelin EffectsPhosphodiesterase function and regulation