The Emerging Role of Innate Immunity in Chronic Kidney Diseases
Philip Chiu‐Tsun Tang, Philip Chiu‐Tsun Tang, Yingying Zhang, Max Kam‐Kwan Chan, Winson Wing-Yin Lam, Jeff Yat‐Fai Chung, Wei Kang, Ka‐Fai To, Hui Y. Lan, Patrick Ming‐Kuen Tang, Patrick Ming‐Kuen Tang
Abstract
Renal fibrosis is a common fate of chronic kidney diseases. Emerging studies suggest that unsolved inflammation will progressively transit into tissue fibrosis that finally results in an irreversible end-stage renal disease (ESRD). Renal inflammation recruits and activates immunocytes, which largely promotes tissue scarring of the diseased kidney. Importantly, studies have suggested a crucial role of innate immunity in the pathologic basis of kidney diseases. This review provides an update of both clinical and experimental information, focused on how innate immune signaling contributes to renal fibrogenesis. A better understanding of the underlying mechanisms may uncover a novel therapeutic strategy for ESRD.