Discovery of N-benzylarylamide derivatives as novel tubulin polymerization inhibitors capable of activating the Hippo pathway
Jian Song, Shenghui Wang, Chun-Hong Song, Weixin Zhang, Junxia Zhu, Xin-Yi Tian, Xiang-Jing Fu, Yan Xu, Cheng‐Yun Jin, Sai‐Yang Zhang
Topics & Concepts
ChemistryTubulinHippo signaling pathwayMicrotubule polymerizationMicrotubuleApoptosisCell cycleColchicineMitosisCell biologyCancer cellCell growthCell cultureBiochemistryCancerBiologyGeneticsHippo pathway signaling and YAP/TAZMicrotubule and mitosis dynamicsCell death mechanisms and regulation