New alkanesulfonate-based quinazolinone-acetohydrazide scaffolds: Rational design, synthesis, molecular docking, anticancer properties and potential EGFR and its T790M/L858R mutants inhibitors
Nagy Morsy, Mohamed A. Omar, Mohamad M. Ebrahium, Aladdin M. Srour
Topics & Concepts
ChemistryQuinazolinoneDocking (animal)T790MMutantCombinatorial chemistryEGFR inhibitorsRational designStereochemistryEpidermal growth factor receptorBiochemistryNanotechnologyReceptorMaterials scienceMedicineGeneGefitinibNursingQuinazolinone synthesis and applicationsSynthesis and biological activityCancer therapeutics and mechanisms