Genetic correlations between subcortical brain volumes and psychiatric disorders
Kazutaka Ohi, Takamitsu Shimada, Yuzuru Kataoka, Toshiki Yasuyama, Yasuhiro Kawasaki, Toshiki Shioiri, Paul M. Thompson
Abstract
Psychiatric disorders as well as subcortical brain volumes are highly heritable. Large-scale genome-wide association studies (GWASs) for these traits have been performed. We investigated the genetic correlations between five psychiatric disorders and the seven subcortical brain volumes and the intracranial volume from large-scale GWASs by linkage disequilibrium score regression. We revealed weak overlaps between the genetic variants associated with psychiatric disorders and subcortical brain and intracranial volumes, such as in schizophrenia and the hippocampus and bipolar disorder and the accumbens. We confirmed shared aetiology and polygenic architecture across the psychiatric disorders and the specific subcortical brain and intracranial volume.