Reversible pH-responsive MRI contrast with paramagnetic polymer micelles
Connor M. Ellis, Daohe Yuan, Ferenc E. Mózes, Jack J. Miller, Jason J. Davis
Abstract
Paramagnetically-doped polymer micelles, containing an ionizable poly(acrylic acid) (PAA) block, support high-contrast MR imaging at clinically relevant field strengths in a manner that is strongly pH responsive. A reversible switch in polymer strand charge specifically has a direct impact on local rigidity, and rotational correlation time characteristics, of the integrated Gd-chelate, driving a ∼50% amplitude switch in positive contrast.
Topics & Concepts
MicellePolymerAcrylic acidRigidity (electromagnetism)ParamagnetismChemistryChelationNuclear magnetic resonanceCopolymerMaterials scienceAqueous solutionInorganic chemistryPhysical chemistryOrganic chemistryPhysicsQuantum mechanicsComposite materialLanthanide and Transition Metal ComplexesAdvanced MRI Techniques and ApplicationsMRI in cancer diagnosis