Shear-Thinning and Designable Responsive Supramolecular DNA Hydrogels Based on Chemically Branched DNA
Bo Yang, Zhihan Zhao, Yufan Pan, Jiayin Xie, Bini Zhou, Yujie Li, Yuanchen Dong, Dongsheng Liu
Abstract
A novel supramolecular DNA hydrogel system was designed based on a directly synthesized chemically branched DNA. For the hydrogel formation, a self-dimer DNA with two sticky ends was designed as the linker to induce the gelation of B-Y. By programing the linker sequence, thermal and metal-ion responsiveness could be introduced into this hydrogel system. This supramolecular DNA hydrogel shows shear-thinning, designable responsiveness, and good biocompatibility, which will simplify the hydrogel composition and preparation process of the supramolecular DNA hydrogel and accelerate its biomedical applications.
Topics & Concepts
Materials scienceSupramolecular chemistrySelf-healing hydrogelsLinkerDNABiocompatibilityDimerNanotechnologyPolymer chemistryMoleculeOrganic chemistryChemistryBiochemistryComputer scienceOperating systemMetallurgyAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliverySupramolecular Self-Assembly in Materials