Nanogels with High Loading of Anesthetic Nanocrystals for Extended Duration of Sciatic Nerve Block
Teresa Alejo, Laura Usón, Guillermo Landa, Martín Prieto, Cristina Yus Argón, Sara García-Salinas, Ricardo de Miguel, Ana Rodríguez‐Largo, Silvia Irusta, Victor Sebastian, Gracia Mendoza, Manuel Arruebo
Abstract
study due to their sustained drug release and excellent biocompatibility. The encapsulation of nano-sized crystals of bupivacaine provides a prolonged regional anesthesia with reduced toxicity, which could be advantageous in the management of chronic pain.
Topics & Concepts
Materials scienceBupivacaineMethacrylateEthylene glycolNanogelLocal anestheticDrug deliveryPolymerPoloxamerChemical engineeringCopolymerNanotechnologyPharmacologyAnesthesiaComposite materialMedicineEngineeringAnesthesia and Pain ManagementPain Mechanisms and TreatmentsAdvanced Drug Delivery Systems