A New Paradigm of the Origins of Circulating DNA in Patients with Cancer
Alain R. Thierry, Ekaterina Pisareva
Abstract
SUMMARY: By shedding light on the cellular origins of circulating DNA (cirDNA), this research provides important insights into the mechanisms of cirDNA production in cancer. Contrary to expectations, the increased cirDNA in patients with cancer was not derived predominantly from neoplastic cells or surrounding nonneoplastic epithelial cells; rather, the excess cirDNA originated primarily from leukocytes, implying a systemic impact of cancer on cell turnover or DNA clearance. See related article by Mattox et al., p. 2166 (1).
Topics & Concepts
Computational biologyCancerDNABiologyMedicineCancer researchGeneticsCancer Genomics and DiagnosticsGenetic factors in colorectal cancerCancer Cells and Metastasis