Psathyrellins A–E, Antibacterial Guanacastane Diterpenoids from Mushroom Psathyrella candolleana
Han‐Chung Wu, Huixiang Yang, Zheng-Hui Li, Tao Feng, Ji‐Kai Liu
Abstract
Five previously undescribed guanacastane diterpenoids, namely psathyrellins A-E (1-5), were obtained from cultures of the mushroom Psathyrella candolleana. Their structures with absolute configurations were elucidated by extensive spectroscopic methods. Compounds 1-3 showed antibacterial activity against four strains with MIC values in a range of 16-128 μg/mL.
Topics & Concepts
MushroomPlant biochemistryAntibacterial activityBioorganic chemistryAgaricalesChemistryBotanyBiologyStereochemistryMicrobiologyBiochemistryBacteriaEnzymeGeneGeneticsTaxonomy (biology)Fungal Biology and ApplicationsMicrobial Natural Products and BiosynthesisMarine Sponges and Natural Products