Molecular subtyping of Alzheimer’s disease using RNA sequencing data reveals novel mechanisms and targets
Ryan Neff, Minghui Wang, Sezen Vatansever, Lei Guo, Ming Chen, Qian Wang, Erming Wang, Emrin Horgusluoglu, Won‐Min Song, Aiqun Li, Emilie L. Castranio, Julia TCW, Lap Ho, Alison Goate, Valentina Fossati, Scott Noggle, Sam Gandy, Michelle E. Ehrlich, Pavel Katsel, Eric E. Schadt, Dongming Cai, Kristen Brennand, Vahram Haroutunian, Bin Zhang
Abstract
We further demonstrate that variations between existing AD mouse models recapitulate a certain degree of subtype heterogeneity, which may partially explain why a vast majority of drugs that succeeded in specific mouse models do not align with generalized human trials across all AD subtypes. Therefore, subtyping patients with AD is a critical step toward precision medicine for this devastating disease.
Topics & Concepts
SubtypingDiseaseAlzheimer's diseaseComputational biologyRNABiologyBioinformaticsGeneticsMedicineGeneComputer sciencePathologyProgramming languageBioinformatics and Genomic NetworksAlzheimer's disease research and treatmentsMachine Learning in Bioinformatics