RNA-binding protein NONO contributes to cancer cell growth and confers drug resistance as a theranostic target in TNBC
Seong‐Jin Kim, Jin‐Sung Ju, Myoung Hee Kang, Ji Eun Won, Young Ha Kim, Prahlad V. Raninga, Kum Kum Khanna, Balázs Győrffy, Chan‐Gi Pack, Hee‐Dong Han, Hee Jin Lee, Gyungyub Gong, Yong Jae Shin, Gordon B. Mills, Seong‐il Eyun, Yun‐Yong Park
Abstract
NONO is an RBP upstream regulator of both STAT3 RNA and protein levels and function. It represents an important and clinically relevant promoter of growth and resistance of TNBCs. NONO is also therefore a potential therapeutic target in TNBC.
Topics & Concepts
Cancer researchTriple-negative breast cancerBiologyCell growthRNA-binding proteinRNA interferenceCancerRegulatorRNAGeneBreast cancerGeneticsRNA Research and SplicingRNA modifications and cancerRNA and protein synthesis mechanisms