Role of Chemical Exchange Saturation Transfer and Magnetization Transfer MRI in Detecting Metabolic and Structural Changes of Renal Fibrosis in an Animal Model at 3T
Anqin Li, Chuou Xu, Ping Liang, Yao Hu, Yaqi Shen, Daoyu Hu, Zhen Li, Ihab R. Kamel
Abstract
OBJECTIVE: To investigate the value of combined chemical exchange saturation transfer (CEST) and conventional magnetization transfer imaging (MT) in detecting metabolic and structural changes of renal fibrosis in rats with unilateral ureteral obstruction (UUO) at 3T MRI. MATERIALS AND METHODS: ) and between magnetization transfer ratio (MTR) derived from MT and alpha-smooth muscle actin (α-SMA). RESULTS: < 0.001). CONCLUSION: CEST and MT could provide metabolic and structural information for comprehensive assessment of renal fibrosis in UUO rats in 3T MRI and may aid in clinical monitoring of renal fibrosis in patients with chronic kidney disease.
Topics & Concepts
MedicineMagnetization transferSaturation (graph theory)FibrosisNuclear magnetic resonancePathologyMagnetic resonance imagingRadiologyMathematicsCombinatoricsPhysicsLanthanide and Transition Metal ComplexesAdvanced MRI Techniques and ApplicationsMRI in cancer diagnosis