Local synthesis of the phosphatidylinositol-3,4-bisphosphate lipid drives focal adhesion turnover
York Posor, Charis Kampyli, Benoît Bilanges, Sushila Ganguli, Philipp Alexander Koch, Alexander Wallroth, Daniele Morelli, Michalina Jenkins, Samira Alliouachene, Elitza Deltcheva, Buzz Baum, Volker Haucke, Bart Vanhaesebroeck
Abstract
-dependent RhoA-GTPase-activating protein ARAP3. Our findings uncover a pathway by which cessation of growth factor signaling facilitates cell-matrix adhesion disassembly via a phosphoinositide lipid switch.
Topics & Concepts
Focal adhesionRHOACell biologyPhosphatidylinositolBiologyCell adhesionGTPasePTK2Signal transductionActin cytoskeletonAdhesionCytoskeletonCellBiochemistryChemistryProtein kinase CMitogen-activated protein kinase kinaseOrganic chemistryCellular transport and secretionCellular Mechanics and InteractionsHippo pathway signaling and YAP/TAZ