Oridonin ameliorates doxorubicin induced-cardiotoxicity via the E2F1/Sirt6/PGC1α pathway in mice
Dongsheng Yu, Jiye Li, Yu Wang, Danfeng Guo, Chunsheng Zhu, Bao Sun, Zheng Zhou
Topics & Concepts
CardiotoxicityDoxorubicinOxidative stressSIRT6SirtuinPharmacologyE2F1Oxidative phosphorylationTranscription factorChemistryMitochondrionApoptosisDownregulation and upregulationCancer researchBiologyBiochemistryMedicineInternal medicineToxicityGeneAcetylationChemotherapyCell death mechanisms and regulationBioactive Natural Diterpenoids ResearchATP Synthase and ATPases Research