The effect of halogenation of salicylaldehyde on the antiproliferative activities of {Δ/Λ-[Ru(bpy)<sub>2</sub>(X,Y-sal)]BF<sub>4</sub>} complexes
Maryam Taghizadeh Shool, Hadi Amiri Rudbari, Tania Gil-Antón, José V. Cuevas, Begoña Garcı́a, Natalia Busto, Nakisa Moini, Olivier Blacque
Abstract
MLCT from the ruthenium center to the salicylaldehyde ligand. The theoretical results are in good agreement with the observed unstructured band at around 520 nm for complexes 2, 4 and 5. Biological studies on human cancer cells revealed that dihalogenated ligands endow the Ru(II) complexes with enhanced cytotoxicity compared to monohalogenated ligands. In addition, as far as the type of halogen is concerned, bromine is the halogen that provides the highest cytotoxicity to the synthesized complexes. All complexes induce cell cycle arrest in G0/G1 and apoptosis, but only complexes bearing Br are able to provoke an increase in intracellular ROS levels and mitochondrial dysfunction.