Convection Enhanced Delivery of Topotecan for Gliomas: A Single-Center Experience
Pavan S. Upadhyayula, Eleonora F. Spinazzi, Michael Argenziano, Peter Canoll, Jeffrey N. Bruce
Abstract
A key limitation to glioma treatment involves the blood brain barrier (BBB). Convection enhanced delivery (CED) is a technique that uses a catheter placed directly into the brain parenchyma to infuse treatments using a pressure gradient. In this manuscript, we describe the physical principles behind CED along with the common pitfalls and methods for optimizing convection. Finally, we highlight our institutional experience using topotecan CED for the treatment of malignant glioma.
Topics & Concepts
TopotecanGliomaParenchymaConvectionMedicineBlood–brain barrierSurgeryChemotherapyCancer researchPathologyInternal medicinePhysicsMechanicsCentral nervous systemGlioma Diagnosis and TreatmentNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranostics