Visible-Light Photoredox-Catalyzed Divergent 1,2-Diacylation and Hydroacylation of Alkenes with Carboxylic Acid Anhydride
Youkang Zhou, Lirong Zhao, Mingyou Hu, Xin‐Hua Duan, Le Liu
Abstract
A photoredox-catalyzed divergent 1,2-dicarbonylation and hydroacylation of alkenes with acid anhydride is presented. This approach offers a mild and efficient entry to 1,4-dicarbonyl compounds bearing all-carbon quaternary centers, exhibiting a broad substrate scope and high functional group compatibility. Hydrocarbonylaltion of alkenes can also be realized by simply introducing a proton source to the reaction system. Mechanism investigations support a radical addition/radical-polar crossover cascade.
Topics & Concepts
HydroacylationChemistryCatalysisPhotochemistryPhotoredox catalysisCarboxylic acidCombinatorial chemistryOrganic chemistryRhodiumPhotocatalysisRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods