Thioredoxin reductase 1 inhibitor shikonin promotes cell necroptosis via SecTRAPs generation and oxygen-coupled redox cycling
Yue Zhang, Shibo Sun, Weiping Xu, Rui Yang, Yijia Yang, Jianli Guo, Kun Ma, Jianqiang Xu
Topics & Concepts
ChemistryProgrammed cell deathBiochemistrySuperoxideCancer cellThioredoxin reductaseThioredoxinReactive oxygen speciesApoptosisOxidative stressBiologyEnzymeCancerGeneticsBioactive Compounds and Antitumor AgentsFree Radicals and AntioxidantsRedox biology and oxidative stress