From acute pulmonary embolism to post-pulmonary embolism sequelae
Ioannis T. Farmakis, Karsten Keller, Stefano Barco, Stavros Konstantinides, Lukas Hobohm
Abstract
Aim of this narrative review is to summarize the functional and hemodynamic implications of acute PE and PE sequelae, namely the post-PE syndrome. Briefly, we will first describe the epidemiology, diagnostic procedures, and therapeutic approaches of acute PE. Then, we will provide a definition of the post-PE syndrome and present the so far accumulated evidence regarding its epidemiology and the implications that arise for further diagnosis and treatment. Lastly, we will explore the most devastating long-term complication of PE, namely chronic thromboembolic pulmonary hypertension (CTEPH), and recent advances in its management.
Topics & Concepts
MedicinePulmonary embolismEpidemiologyIntensive care medicineChronic thromboembolic pulmonary hypertensionComplicationNarrative reviewPulmonary hypertensionCardiologyInternal medicineVenous Thromboembolism Diagnosis and ManagementPulmonary Hypertension Research and TreatmentsCardiovascular Effects of Exercise