Hydrogen sulfide triggered molecular agent for imaging and cancer therapy
Chao Ge, Xiaojiao Di, Siqi Han, Mengmeng Wang, Xiaoting Qian, Zhi Su, Hong‐Ke Liu, Yong Qian
Abstract
We developed an activatable molecular reagent, PNF, triggered by intracellular H2S in the lysosome to release the therapeutic drug amonafide, which can escape from the lysosome into the nucleus to induce autophagy of cancer cells. PNF exhibits potent inhibitory activity against cisplatin-resistant tumor cell lines.
Topics & Concepts
LysosomeAutophagyIntracellularHydrogen sulfideCancer cellChemistryCancer therapyCancerBiophysicsCancer researchCell biologyBiochemistryMedicineSulfurBiologyEnzymeInternal medicineOrganic chemistryApoptosisSulfur Compounds in BiologyPolyamine Metabolism and ApplicationsAmino Acid Enzymes and Metabolism