Cell death affecting the progression of gastric cancer
Haoying Wang, Mengxiao Liu, Xi Zeng, Ya Zheng, Yuping Wang, Yongning Zhou
Abstract
Gastric cancer is a gastrointestinal tumor with high morbidity and mortality rates. Several factors influence its progression, cell death being an important element. In this review, we summarized the effects of necrosis, apoptosis, necroptosis, pyroptosis, ferroptosis, and eight less common cell death modalities on gastric cancer cells and the tumor microenvironment, detailed the molecular mechanisms of various cell death and their major regulatory pathways in gastric cancer, explored the prevalence and complexity of cell death in gastric cancer progression and highlighted the potentials of cell death-related therapies in gastric cancer.
Topics & Concepts
CancerProgrammed cell deathApoptosisMedicineCancer researchInternal medicineBiologyGeneticsHelicobacter pylori-related gastroenterology studiesGenomics, phytochemicals, and oxidative stressNF-κB Signaling Pathways