Role of pericytes in the development of cerebral cavernous malformations
Zifeng Dai, Jingwei Li, Ying Li, Rui Wang, Huili Yan, Ziyu Xiong, Shi‐Ting Wu, Xi Yang, Dongbo Lu, Dongdong Zhang, Guo‐Fu Li, Yuwen Wang, Chunyang Men, Wenzhong Du, Xiangjian Zheng, Changbin Shi
Abstract
mice. Also, human CCM lesions had abundant fibronectin deposition, and pSMAD3- and KLF4-positive pericytes. These findings indicate that pericytes are essential for CCM lesion development, and fibronectin intervention may provide a novel target for therapeutic intervention in such patients.
Topics & Concepts
PericyteFibronectinLesionKLF4Cell biologyBiologyCancer researchGenePathologyMedicineEndothelial stem cellIn vitroGeneticsTranscription factorExtracellular matrixSOX2Vascular Malformations Diagnosis and TreatmentIntracerebral and Subarachnoid Hemorrhage ResearchIntracranial Aneurysms: Treatment and Complications