Structural insights into the G protein selectivity revealed by the human EP3-Gi signaling complex
Ryoji Suno, Yukihiko Sugita, Kazushi Morimoto, Hiroko Takazaki, Hirokazu Tsujimoto, Mika Hirose, Chiyo Suno-Ikeda, Norimichi Nomura, Tomoya Hino, Asuka Inoue, Kenji Iwasaki, Takayuki Kato, So Iwata, Takuya Kobayashi
Abstract
that have been previously reported and examine the differences in amino acid composition at the receptor-G protein interface. Mutational analysis reveals that the selectivity of the G protein depends on specific amino acid residues in the second intracellular loop and TM5.
Topics & Concepts
Signal transductionCell biologyChemistryComputational biologyBiologyProtein Kinase Regulation and GTPase SignalingATP Synthase and ATPases ResearchEnzyme function and inhibition